Escitalopram oxalate synthesis
- Product Name:Escitalopram oxalate
- CAS Number:219861-08-2
- Molecular formula:C22H23FN2O5
- Molecular Weight:414.43
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128196-01-0
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219861-08-2
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Yield:219861-08-2 98.57%
Reaction Conditions:
in acetone at 25 - 30;Industry scale;
Steps:
2
Preparation of Escitalopram OxalateThe residue obtained in Example 1 was dissolved in acetone (120 lit) at 25-30° C. A solution of oxalic acid dihydrate (17 Kg, 0.135 kmoles) in acetone (34 lit) was introduced over 30 minutes. The reaction mass was stirred for 2 hrs, cooled to 10° C. and further stirred for 1 hr. The solid obtained was isolated by filtration, washed with acetone (2×40 lit) and dried in a vacuum oven for 4-5 hrs at 50-55° C. to obtain the title compound.Yield: 40.0 Kg, 98.57%Chiral purity:->99.5%
References:
US2010/204493,2010,A1 Location in patent:Page/Page column 8
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144-62-7
840 suppliers
$5.00/5g
219861-08-2
576 suppliers
$5.00/100mg