EthanediaMide iMpurity D synthesis
- Product Name:EthanediaMide iMpurity D
- CAS Number:480452-36-6
- Molecular formula:C21H30ClN5O5
- Molecular Weight:467.95
365998-36-3
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349125-08-2
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480452-36-6
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Yield:480452-36-6 93%
Reaction Conditions:
with sodium acetate in N,N-dimethyl-formamide at 90; for 7 h;Reagent/catalyst;Temperature;Solvent;
Steps:
1-4 Example 2
DMF (120g) was placed in a 500mL reaction flask,Compound A (22.5 g, 0.079 mol, 1.00 eq.) was added successively,Compound B (18.9g, 0.083mol, 1.05eq.) and sodium acetate (9.7g, 0.118mol, 1.50eq.) were heated to 90° C. to react for 7h. Add 240g of water,Incubate the reaction at 85 °C for 1 h,There is solid precipitation,Suction filtration, the filter cake was rinsed with water,Compound I obtained after drying was off-white solid 34.3g,Yield: 93.0%,Purity: 98.9%.
References:
CN113968813,2022,A Location in patent:Paragraph 0038-0049
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