一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Edoxaban Impurity 16
480450-69-9

Edoxaban Impurity 16 synthesis

11synthesis methods
-

Yield: 75.9%

Reaction Conditions:

Stage #1:(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-N,N-dimethylcyclohexanecarboxamide with diphenyl phosphoryl azide;1,8-diazabicyclo[5.4.0]undec-7-ene in toluene at 45 - 50;
Stage #2: with potassium carbonate in toluene at 100 - 105;

Steps:

2 Example 2 Synthesis of tert-butyl N-[(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate
Toluene (3000g) was added to the reaction flask, then 109B6-01 (600g; 2.095mol) was added, DBU (420g; 2.759mol) was added, and diphenyl azide phosphate (DPPA) (750g; 2.725mol) was added. Heat to 45-50°C to react for 2-3hrs, then add anhydrous potassium carbonate (500g; 3.618mol), continue to heat up to 100-105°C, stir and react for 36-40hr.After the reaction is completed, cool to 4050, add water (3000g) to the reaction system, keep it at 4045, stir and extract, keep the water phase at 4045, and extract three times with toluene (1200g+600g× 2); Combine the organic phases; dry with anhydrous sodium sulfate, filter, collect the filtrate, and concentrate toluene under reduced pressure to obtain a residue; add ethyl acetate and n-heptane (1:3, w/w) to the residue , Stir and crystallize at room temperature; filter, collect the solid, and dry to obtain 109B8-01 with a dry weight of about 495g. Yield: 75.9% (theoretical amount: 652.40 g).

References:

Inner Mongolia Jingdong Pharmaceutical Co., Ltd.;Lv Guanfeng;Xiao Jiang;Guo Rongyao CN111606827, 2020, A Location in patent:Paragraph 0046-0048

Edoxaban Impurity 16 Related Search:

开平市| 商城县| 申扎县| 盱眙县| 宝清县| 忻城县| 肃南| 当涂县| 白城市| 河西区| 长汀县| 东平县| 叙永县| 玉田县| 德化县| 盐源县| 曲麻莱县| 七台河市| 连平县| 巩留县| 汪清县| 丰顺县| 花莲市| 武平县| 汝城县| 盐津县| 高雄市| 凌源市| 江山市| 西丰县| 新营市| 临洮县| 东台市| 八宿县| 嘉黎县| 宜昌市| 泗洪县| 天柱县| 东海县| 称多县| 邵阳市|