Ethyl 2-(2,4,5-trifluorophenyl)acetate synthesis
- Product Name:Ethyl 2-(2,4,5-trifluorophenyl)acetate
- CAS Number:1256470-41-3
- Molecular formula:C10H9F3O2
- Molecular Weight:218.17
64-17-5
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209995-38-0
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1256470-41-3
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$21.00/100mg
Yield:1256470-41-3 97%
Reaction Conditions:
with sulfuric acid at 0; for 4 h;Reflux;
Steps:
Synthesis of ethyl-2-(2,4,5-trifluorophenyl)acetate (2)
To solution of 2,4,5-trifluorophenyl acetic acid (1, 6 g, 31.57 mmol) in ethanol (50 mL) was added catalytic amount of H2SO4 at 0 °C followed by reflux for about 4 h. The reaction was monitored by TLC; after reaction completion, ethanol was distilled off. The reaction mass was poured into cold distilled water (100 mL) then extracted with EtOAc twice (2 9 50 mL). Later, the ethyl acetate layer was washed with distilled water twice (2 9 50 mL) to remove acid traces then dried over Na2SO4 (2 g, 17 mmoles). The total EtOAc layer was distilled off, and ethyl-2-(2,4,5-trifluorophenyl)acetate (2) finally obtained (6.67 g, 97% yield) as colorless oil. Analytical data: 1H NMR (400 MHz, DMSO-d6): d 7.54-7.43 (m, 2H), 4.26 (s,2H), 3.92 (m, 2H), 1.38 (t, 3H); LC-MS: m/z 219 (M + H)+.
References:
Ramesh, Navudu;Gangadhara Rao, Mannem;Vasu Babu;Nagababu;Umamaheswara Rao;Hari Babu [Research on Chemical Intermediates,2017,vol. 43,# 7,p. 4145 - 4164]
327-52-6
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105-36-2
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1256470-41-3
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$21.00/100mg
446-17-3
415 suppliers
$6.00/5g
1256470-41-3
30 suppliers
$21.00/100mg