ethyl 6-hydroxy-2,4-diMethylnicotinate synthesis
- Product Name:ethyl 6-hydroxy-2,4-diMethylnicotinate
- CAS Number:36853-14-2
- Molecular formula:C10H13NO3
- Molecular Weight:195.22
41867-20-3
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36853-14-2
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Yield: 29%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;toluene at 115;
Steps:
1
(E) -Ethyl 3-aminobut-2-enoate (2.53 g, 19.6 mmol) in toluene (15 mL) was charged with 4N HCl (10 mL, 40 mmol) in dioxane. The mixture was stirred at 115°C overnight. The solution was cooled and the solid was filtered off washing with toluene. The filtrate was concentrated and the residue was purified by silica gel column chromatography (5% MeOH/EtOAc) to
References:
TAKEDA PHARMACEUTICAL COMPANY LIMITED WO2008/11131, 2008, A2 Location in patent:Page/Page column 251-252
5977-14-0
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89095-42-1
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3385-34-0
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