Ethyl isobutyrate synthesis
- Product Name:Ethyl isobutyrate
- CAS Number:97-62-1
- Molecular formula:C6H12O2
- Molecular Weight:116.16
64-17-5
857 suppliers
$10.00/50g
79-31-2
458 suppliers
$18.00/25mL
97-62-1
280 suppliers
$16.60/100G
Yield:97-62-1 68.9%
Reaction Conditions:
with toluene-4-sulfonic acid in cyclohexane;Reflux;
Steps:
To a solution of isobutyric acid (88.0 g, 1 mol) in ethanol(90 mL) and cyclohexane (20 mL), p-toluenesulfonic acid(1.8 g, 2%) was added. The reaction was refluxed until nowater appeared in water separator. The mixture was cooleddown and washed by water, saturated sodium bicarbonateaqueous solution and saturated sodium chloride,respectively, then dried over anhydrous magnesium sulfate.After cyclohexane was removed by distillation under vacuum,then 109-113 °C distillate was collected to get ethylisobutyrate (58.0 g, 0.5 mol). Yield: 68.9%.
References:
Li, Zhenyu;Cao, Yuan;Zhan, Peng;Pannecouque, Christophe;Balzarini, Jan;De Clercq, Erik;Shen, Yuemao;Liu, Xinyong [Medicinal Chemistry,2013,vol. 9,# 7,p. 968 - 973]
64-17-5
857 suppliers
$10.00/50g
96-05-9
216 suppliers
$21.00/25mL
644-49-5
71 suppliers
$33.00/25mL
97-62-1
280 suppliers
$16.60/100G
64-17-5
857 suppliers
$10.00/50g
759-05-7
125 suppliers
$50.00/50mg
97-62-1
280 suppliers
$16.60/100G
7505-94-4
11 suppliers
inquiry
97-62-1
280 suppliers
$16.60/100G
