Ethyl propionate synthesis
- Product Name:Ethyl propionate
- CAS Number:105-37-3
- Molecular formula:C5H10O2
- Molecular Weight:102.13
Yield:105-37-3 99.13%
Reaction Conditions:
with Dowex 50W×2 hydrogen form resin at 107 - 110;Autoclave;Large scale;Reagent/catalyst;
Steps:
3 (Example 3 Ethyl propionate)
(1) Before the esterification reaction,To a capacity of 1000L distillation tower reactor,400 kg of propionic acid (chemically pure)And 20 kg of a gel type strongly acidic ion exchange resin catalyst.The particle size of the gel type strongly acidic ion exchange resin catalyst is produced by Dow Chemical is 100mesh to 200mesh of Dowex 50W × 2 hydrogen form resin,The resin is in the form of solid particles,The main component is a hydrogen-type sulfonic acid group with styrene-stilbene copolymer,The degree of cross-linking was 2%. After wetting,The resin has a pore size of 2 nm to 4 nm.(2) heating reactor,The inside temperature of the autoclave was controlled to 107 ° C to 110 ° C,The contents of the reaction vessel were continuously stirred,The stirring speed was 800 rpm / min.And continuously fed into the reaction vessel at a rate of 1.2 L / minPropionic acid (chemically pure) and ethanol (chemically pure)And the mixture was subjected to an esterification reaction,The molar ratio of propionic acid to ethanol was 6: 5.(3) the filtered esterification reaction product is allowed to stand in a water separator,Separating water from the bottom of the water separator,An azeotropic mixture of ethyl propionate and ethanol was separated from the top of the water separator.Adding an extractant in the azeotropic mixture liquid,The extractant is ethylene glycol,The mass ratio of extractant to azeotropic mixture was 1:10.The number of plates in the distillation column was 16,The column top temperature of the distillation column was controlled to 89.5 ° C to 99.7 ° C, the reflux ratio was controlled to be 4: 1,From the top of the ethyl propionate extraction products.Chromatographic analysis of ethyl propionate in the ester content of 99.9%,The acid value was 0.81 mgKOH / g.Based on the concentration and mass of reactants and products,The yield of ethyl propionate was 99.13%.
References:
CN104761451,2016,B Location in patent:Paragraph 0034; 0035; 0036; 0037; 0038; 0039
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