Ethylazidoformate synthesis
- Product Name:Ethylazidoformate
- CAS Number:817-87-8
- Molecular formula:C3H5N3O2
- Molecular Weight:115.0907
541-41-3
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Yield: 80%
Reaction Conditions:
with sodium azide in diethyl ether;water at 20;Cooling with ice;
Steps:
General procedure: Sodium azide (157 mmol) was dissovled in 55 mL of H2O and cooled in an icebath. Ethyl chloroformate (131 mmol) in 15 mL of diethyl ether was thenadded to the aqueous sodium azide. The reaction was stirred vigorouslyovernight, warming to room temperature. The reaction was extracted intodiethyl ether (2 40 mL) and the organics were dried over MgSO4 andconcentrated under reduced pressure. EAF was isolated as a transparent oil in80% yield. CAUTION: ethyl azidoformate can decompose explosively attemperatures above 160 C.
References:
McLaughlin, Emily C.;Shrestha, Anuska;Fletcher, Madison H.;Steinauer, Nathaniel S.;Shinn, Min Kyung;Shahid, Sabrina M. [Tetrahedron Letters,2013,vol. 54,# 40,p. 5461 - 5463]
623-33-6
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4114-31-2
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57-14-7
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1972-28-7
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687-48-9
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6130-87-6
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4114-28-7
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