Felodipine 3,5-DiMethyl Ester synthesis
- Product Name:Felodipine 3,5-DiMethyl Ester
- CAS Number:91189-59-2
- Molecular formula:C17H17Cl2NO4
- Molecular Weight:370.23
105-45-3
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6334-18-5
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14205-39-1
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91189-59-2
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$185.00/100mg
Yield: 82.1%
Reaction Conditions:
in methanol at 60; for 10 h;Temperature;Solvent;
Steps:
1 Example 1:
To the reaction flask was added 80 mL of methanol,Under stirring, 2,3-dichlorobenzaldehyde (14 g, 0.08 mol)3-amino crotonic acid methyl ester (9.2 g, 0.08 mol) aAcetoacetate (9.3 g, 0.08 mol),Then heated to 60 ° C,Avoid light reaction for 10h. The reaction solution was poured into a single-necked flask, concentrated at 40 ° C under reduced pressure to dryness, and 80 mL of anhydrous ether was added. The mixture was beaten for 2 hours. The filter was added to 40 mL of methanol, dissolved at 65 ° C, stirred to room temperature, ~ 5 cold overnight, the next day filter,The filter cake was dried in vacuo at 50 ° C to give 24.3 g of the product as a pale yellow solid (i.e., clavuline butyrate), yield 82.1%, purity (HPLC): 98.72%.
References:
Bengbu Fengyuan Pharmaceutical Co., Ltd.;Li Libiao;Zhang Jin;Zheng Ai;Chen Yun;Hu Yuan CN106748974, 2017, A Location in patent:Paragraph 0026-0034
105-45-3
701 suppliers
$5.00/5g
6334-18-5
420 suppliers
$6.00/10g
91189-59-2
100 suppliers
$185.00/100mg
6334-18-5
420 suppliers
$6.00/10g
91189-59-2
100 suppliers
$185.00/100mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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124-41-4
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105618-03-9
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91189-59-2
100 suppliers
$185.00/100mg