Fmoc-L-Serine synthesis
- Product Name:Fmoc-L-Serine
- CAS Number:73724-45-5
- Molecular formula:C18H17NO5
- Molecular Weight:327.33
Yield:73724-45-5 88%
Reaction Conditions:
with sodium carbonate in 1,4-dioxane;water at 20; for 1 h;Cooling with ice;
Steps:
N-(9-Fluorenylmethoxycarbonyl)-L-serine (10)
To a solution of L-serine (3) (103 mg, 0.98 mmol) in aqueous10% sodium carbonate (3 mL) cooled on an ice bath was slowly added a solution of 9-fluorenylmethoxycarbonyl chloride (245 mg, 0.95 mmol) in 1,4-dioxane (3 mL). After stirring for 1 h at rt, themixture was washed with EtOAc to remove byproducts, added with 1M HCl, and extracted with EtOAc. Theorganic layer was washed with brine, dried over MgSO4, and evaporated to give 10 as a white solid (284 mg,88%). The spectral data of 10 were identical to the literature.33 The purity was confirmed by 1H NMR.
References:
Shimodaira, Shingo;Iwaoka, Michio [Arkivoc,2016,vol. 2017,# 2,p. 260 - 271]
56-45-1
812 suppliers
$5.00/25g
82911-69-1
662 suppliers
$7.00/25g
73724-45-5
350 suppliers
$5.00/1g
82911-78-2
96 suppliers
$15.00/250mg
73724-45-5
350 suppliers
$5.00/1g
![L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(triphenylmethyl)-, methyl ester](/CAS/20210111/GIF/171820-89-6.gif)
171820-89-6
3 suppliers
inquiry
73724-45-5
350 suppliers
$5.00/1g
