ChemicalBook CAS DataBase List Hexaethylene Glycol Monomethyl Ether

Hexaethylene Glycol Monomethyl Ether synthesis

12synthesis methods

Product Name:Hexaethylene Glycol Monomethyl Ether
CAS Number:23601-40-3
Molecular formula:C13H28O7
Molecular Weight:296.36

HexaethyleneGlycolMonomethylEther can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly in laboratory research and development. It can be synthesized by condensation reaction of Hexaethylene glycol and Iodomethane.

62921-74-8 Synthesis

2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate

62921-74-8
80 suppliers
$71.00/1G

112-27-6 Synthesis

112-27-6
784 suppliers
$6.00/100g

23601-40-3
177 suppliers
$15.00/250mg

Yield:23601-40-3 69%

Reaction Conditions:

with potassium hydroxide at 100; for 12 h;

Steps:

3.1 Step 1; Preparation of 2,5,8,11, 14,17-hexaoxanonadecan-19-ol
2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (Al, 1.0 g, 3.14 mmol) was added with stir to triethylene glycol (2.10 mL, 15.7 mmol). Potassium hydroxide (510 mg, 9.42 mmol) was ground into a powder and added to the reaction and the mixture refluxed at 100°C for 12 hours, upon which the reaction was diluted with water (50 mL) and extracted with DCM. The organic layers were combined, dried over sodium sulfate, and concentrated under reduced pressure to obtain 2,5,8,1 l,14,17-hexaoxanonadecan-19-ol as a yellow oil in 69% yield.

References:

AMYDIS DIAGNOSTICS;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;YANG, Jerry;THEODORAKIS, Emmanuel, A.;SARRAF, Stella WO2015/143185, 2015, A1 Location in patent:Paragraph 00819

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2615-15-8 Synthesis