Imperatorin synthesis
- Product Name:Imperatorin
- CAS Number:482-44-0
- Molecular formula:C16H14O4
- Molecular Weight:270.28
2009-24-7
207 suppliers
$50.00/25mg
870-63-3
297 suppliers
$26.00/5g
482-44-0
306 suppliers
$15.00/5mg
Yield:482-44-0 58.7%
Reaction Conditions:
with sodium carbonate in N,N-dimethyl-formamide at 50; for 5 h;
Steps:
1.1.17 (17) Synthesis of Compound B17
Compound B1 (107.2 mg, 0.53 mmol) was dissolved in 4 mL of dimethylformamide and sodium carbonate was added.(168.5 mg, 1.59 mmol) was stirred, then 1-bromo-3-methyl-2-butene (236.9 mg, 1.5 mmol) was added to the mixture.In the liquid, transfer to a constant temperature magnetic stirrer and stir at 50 ° C for 5 h. The reaction was completed by TLC. 10 mL of 1 M hydrochloric acid was added dropwise to the mixture, extracted with chloroform (3×20 mL), and the organic phase was extracted with saturated brine (2×10 mL).Concentrated by pressure and mixed with silica gel column chromatography. The elution system was petroleum ether: ethyl acetate = 10:1. Enrich the target,After drying, 84.2 mg of a white solid (i.e., compound B17) was obtained. Yield: 58.7%.
References:
Beijing Agricultural College;Liu Chunmei;Zhao Ying;Li Bing;Wang Sai;Zhu Huize;Sun Yu CN109503612, 2019, A Location in patent:Paragraph 0076; 0084; 0118-0119
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298-81-7
421 suppliers
$7.00/10mg
482-44-0
306 suppliers
$15.00/5mg