Indole-5-carboxaldehyde synthesis
- Product Name:Indole-5-carboxaldehyde
- CAS Number:1196-69-6
- Molecular formula:C9H7NO
- Molecular Weight:145.16
Yield:1196-69-6 95%
Reaction Conditions:
Stage #1:indole;formic acid ethyl ester at 35 - 45; for 1 h;Inert atmosphere;
Stage #2: with zinc(II) chloride at 45 - 55; for 12 h;Inert atmosphere;Reagent/catalyst;
Steps:
1-4 Example 1
At room temperature, 500 ml of ethyl formate and 117 g of indole were added to the reaction flask under the protection of nitrogen.The mixture was warmed to 35-45 ° C and stirred for 1 h.At room temperature, add 272g of zinc chloride under the reaction flask.Heated to 45-55 degrees and refluxed for 12h,Filtrate while hot, reduce the temperature to -10 degrees, and filter to obtain 140 g of 5-aldehyde indole as a pale yellow solid.Yield: 95%, purity: 99.98%.
References:
Suzhou Yongjian Bio-pharmaceutical Co., Ltd.;Gao Yuan;Cui Huaijie;Zong Yanglei CN110734390, 2020, A Location in patent:Paragraph 0011; 0016-0023
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