Isovaleraldehyde synthesis
- Product Name:Isovaleraldehyde
- CAS Number:590-86-3
- Molecular formula:C5H10O
- Molecular Weight:86.13
6135-52-0
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590-86-3
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Yield:590-86-3 98%
Reaction Conditions:
with chloral hydrate in hexane at 25; for 1.5 h;Inert atmosphere;
Steps:
3
General procedure: A stirred solution of the acetal (2, 3.5 mmol) in dry hexane (5 ml), under dry nitrogen at 25 C, was treated with 1 (1.7 g, 10.6 mmol). The mixture was stirred for 2 h, treated with water, and extracted with dichloromethane (10 ml). The extracts were washed with brine solution, dried (Na2SO4), and concentrated in vacuo. The resulting residue was purified by column chromatography on neutral alumina(50-325 mesh, eluent: 2.5:97.5 ethyl acetate-hexane), to obtain the corresponding carbonyl compound (3). The purity was estimated to be >98% by 1H and 13C NMRspectroscopic analysis. In the case of solid acetals, 0.5 ml of dichloromethane along with hexane was added for added solubility; in the case of thioacetals, 21.2 mmol of 1 was used fo reffective deprotection
References:
Chandrasekhar, Sosale;Shrinidhi, Annadka [Synthetic Communications,2014,vol. 44,# 13,p. 1904 - 1913]
123-51-3
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590-86-3
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187737-37-7
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201230-82-2
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110-62-3
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$13.44/25ML
590-86-3
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556-82-1
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$19.00/25g
590-86-3
385 suppliers
$10.00/5g
