Itraconazole synthesis
- Product Name:Itraconazole
- CAS Number:84625-61-6
- Molecular formula:C35H38Cl2N8O4
- Molecular Weight:705.63
![2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one](/CAS/GIF/252964-68-4.gif)
252964-68-4
106 suppliers
$80.00/25mg
84625-61-6
779 suppliers
$6.00/100mg
Yield:-
Steps:
Multi-step reaction with 2 steps
1: hydrogen bromide / lithium hydroxide monohydrate; toluene / 12 h / Reflux
2: potassium carbonate / (methylsulfinyl)methane / 5 h / 90 °C
References:
Cai, Jin;Chen, Xixi;You, Haoyuan;Li, Xiaojing;Ji, Min [Bioorganic and Medicinal Chemistry Letters,2022,vol. 76,art. no. 129011]
![2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE](/CAS/GIF/106461-41-0.gif)
106461-41-0
193 suppliers
$110.00/25mg
67914-86-7
204 suppliers
$25.00/1g
84625-61-6
779 suppliers
$6.00/100mg
![2,4-dihydro-4-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one](/CAS/GIF/74853-07-9.gif)
74853-07-9
62 suppliers
$55.00/10mg
84625-61-6
779 suppliers
$6.00/100mg