L-carnitine synthesis
- Product Name:L-carnitine
- CAS Number:541-15-1
- Molecular formula:C7H15NO3
- Molecular Weight:161.2
Yield:541-15-1 98.8%
Reaction Conditions:
with triethylamine in water monomer at 0 - 25; for 0.0666667 h;Flow reactor;Temperature;
Steps:
1.2-11.2 (2) Preparation of L-carnitine (Compound A) in a continuous flow tubular reactor, as shown in Figure 2
Preparation of material C: trimethylamine (20mol, 5910g) dissolved in purified water, preparation of 20% aqueous solution of trimethylamine, placed in raw material tank C; Preparation material D: Compound C (10mol, 1300g) placed in raw material tank D, standby; By changing the flow rate to control the molar ratio of Compound C and Compound B, the molar ratio of compound C and Compound B is 1:2, and the materialSC and D are transported together to a continuous flow tube reactor, reacted for 60s at 0 °C, and then heated up to 25 °C, and the continuous reaction is 180s, and the ring-opening reaction occurs; the heat exchange medium is ethylene glycol or a mixture of water and ethylene glycol; After the end of the reaction, the excess unreacted trimethylamine was removed by reduced pressure distillation, and then the pH of concentrated hydrochloric acid was adjusted to 5 to 6 dropwise, and then the crystals were purified to give a white crystal of 15.9g and a yield of 98.8%. the total yield of the two-step reaction was 95.7%, and the purity of l-carnitine was 99.6%.
References:
CN113929589,2022,A Location in patent:Paragraph 0055-0060; 0067-0069
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