L-Glutamine synthesis
- Product Name:L-Glutamine
- CAS Number:56-85-9
- Molecular formula:C5H10N2O3
- Molecular Weight:146.14
13726-85-7
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56-85-9
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$5.00/5g
Yield:56-85-9 40%
Reaction Conditions:
with trifluoroacetic acid at 0 - 35;Reagent/catalyst;Temperature;
Steps:
1; 3.II.C L-Glutamine preparation:
Trifluoroacetic acid (4 vol) was added to the above gummy mass (obtained from the above reaction) at 0-10°C and the reaction mass was allowed to heat at 25- 35°C and stirred for 2-3 hrs. After completion of the reaction, the excess TFA was distilled under reduced pressure and aqueous ammonia (4 vol) was added then distilled ~ 2 vol under reduced pressure at below 55°C. Methanol (6 vol) was added to the aqueous mass at 25-35°C and cooled to 0-10°C then stirred for 1 hr. The obtained white solid was filtered and washed with methanol (2 vol). The titled compound was dried under reduced pressure at 70-75°C for ~5 hrs to get the 40% of the theoretical yield.
References:
WO2022/13706,2022,A1 Location in patent:Page/Page column 13; 14; 15; 16
71989-20-3
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56-85-9
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2490-97-3
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$5.00/100mg
56-85-9
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56-86-0
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$5.00/25g
56-85-9
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