LCZ696 InteMediate synthesis
- Product Name:LCZ696 InteMediate
- CAS Number:1426129-50-1
- Molecular formula:C20H25NO3
- Molecular Weight:327.42
128779-47-5
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1426129-50-1
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Yield:1426129-50-1 95.1%
Reaction Conditions:
with sulfuric acid;ruthenium-carbon composite;hydrogen in water at 90; pH=1 - 3; under 60006 Torr; for 8 h;
Steps:
5.1.2; 5.2.2; 5.3.2
(2) Take 135g of BOC-D-biphenylalanine obtained in step (1) and add it to 650ml of water,Acidify with H2SO4 to PH=1-3, add 2.7g of metal catalyst (Ru/C), and after passing hydrogen for 0.5h,Raise the temperature to 90°C, keep the pressure at 8Mpa and react for 8h,After the reaction is completed, the metal catalyst is filtered off, and the filtrate is concentrated to a small volume. The metal catalyst and the filtrate are distilled and recovered. After the concentration is completed, 100 ml of an alkaline alcohol mixed solution is added to stir and crystallize.Filtration to obtain 129.1g (R)-2-(N-tert-butoxycarbonylamino) biphenylpropanol,The purity was 99.5% and the yield was 95.1%.
References:
CN111205204,2020,A Location in patent:Paragraph 0078; 0082; 0084; 0086; 0088; 0090; 0092
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1426129-51-2
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1426129-50-1
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