Losartan Carboxaldehyde synthesis
- Product Name:Losartan Carboxaldehyde
- CAS Number:114798-36-6
- Molecular formula:C22H21ClN6O
- Molecular Weight:420.89
114798-26-4
277 suppliers
$6.00/250mg
114798-36-6
104 suppliers
$50.00/1mg
Yield:114798-36-6 94%
Reaction Conditions:
with dipyridinium dichromate in N,N-dimethyl-formamide at 20 - 50; for 6 h;Alkaline conditions;
Steps:
2.2 (2) 5-aldehyde losartan
317g of losartan (0.75mol) was dissolved in DMF (1000mL) and was added in portions with stirring 418.5g of PDC. Temperature was not to exceed 50°C. After addition of PDC was complete, it was stirred at room temperature for 6 hours. The reaction solution was poured into 5000g of water. The solution was extracted three times with ethyl acetate (2500mL × 3). The combined organic phases was washed saturated brine (2500mL) then dried over anhydrous magnesium sulfate. it was filtered and concentrated to give 296g of a solid 5-aldehyde losartan, yield 94%
References:
CN105218527,2016,A Location in patent:Paragraph 0015
![Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde](/CAS/20200611/GIF/124750-67-0.gif)
124750-67-0
29 suppliers
inquiry
114798-36-6
104 suppliers
$50.00/1mg
![1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-[1-[(4-methoxyphenyl)methyl]-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-](/CAS/20210305/GIF/1307853-51-5.gif)
1307853-51-5
0 suppliers
inquiry
114798-36-6
104 suppliers
$50.00/1mg
124750-99-8
833 suppliers
$5.00/1g
114798-36-6
104 suppliers
$50.00/1mg
124750-92-1
176 suppliers
$7.00/1mg
133910-00-6
15 suppliers
inquiry
114798-36-6
104 suppliers
$50.00/1mg