METHAQUALONE synthesis
- Product Name:METHAQUALONE
- CAS Number:72-44-6
- Molecular formula:C16H14N2O
- Molecular Weight:250.3
Yield:72-44-6 98%
Reaction Conditions:
Stage #1:ethanol with oxygen;eosin y in dimethyl sulfoxide at 25; for 20 h;Sealed tube;Irradiation;Green chemistry;
Stage #2:2-amino-N-(2-methylphenyl)benzamide with toluene-4-sulfonic acid in dimethyl sulfoxide at 25; for 24 h;Sealed tube;Irradiation;Green chemistry;Reagent/catalyst;Wavelength;Temperature;Solvent;
Steps:
1 Preparation of 2-methyl-3-(o-tolyl)quinazolin-4 (3H)-one
In a closed quartz reaction tube, ethanol (0.6 mmol), photosensitizer Eosin Υ (lmmol%) and DMSO (2 mL) were added, and the reaction was carried out under a condition of oxygen and 25 °C for 20 hours under irradiation of a xenon lamp (400 to 720 nm); Then, 2-amino-N-(o-tolyl)benzamide (0.2 mmol) and PTSA (2 mmol%) were added to the quartz reaction tube under irradiation with a xenon lamp (400 to 720 nm), oxygen and 25 °C. After reacting for 24 hours, after the reaction is completed, the mixture is distilled under reduced pressure and separated by column chromatography (ΕΑ: ΡΕ = 1:8) to obtain a target compound.98% yield of the target compound 2-methyl-3-(o-tolyl)quinazoline-4(3H)-one
References:
Henan University;Xu Hao;Xia Qiangqiang;Ren Yanrong;Liu Baoying;Wang Yanpeng;Xu Yuanqing;Zhang Wenkai;Ding Tao;Fang Xiaomin;Liu Junxia CN108822046, 2018, A Location in patent:Paragraph 0027; 0029; 0030; 0032; 0034; 0037; 0038
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