METHYL 2-FLUORO-4-HYDROXYBENZOATE synthesis
- Product Name:METHYL 2-FLUORO-4-HYDROXYBENZOATE
- CAS Number:197507-22-5
- Molecular formula:C8H7FO3
- Molecular Weight:170.14
67-56-1
65145-13-3
197507-22-5
General procedure for the synthesis of methyl 2-fluoro-4-hydroxybenzoate from methanol and 2-fluoro-4-hydroxybenzoic acid: Referring to Example 10 of the literature; 2-fluoro-4-hydroxybenzoic acid (50.0 g) was dissolved in methanol (700 mL), concentrated sulfuric acid (10 mL) was added as a catalyst, and the reaction was carried out with heating and stirring for 16 hrs. at 90 °C. After the reaction was completed, the reaction solution was concentrated, and the resulting colorless crystals were washed with water and dried to obtain the target product methyl 2-fluoro-4-hydroxybenzoate (51 g, 94% yield) as colorless crystals. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 3.79 (3H, s), 6.61-6.72 (2H, m), 7.73-7.79 (1H, m), 10.80 (1H, br).
67-56-1
793 suppliers
$7.29/5ml-f
65145-13-3
194 suppliers
$10.00/1g
197507-22-5
114 suppliers
$6.00/100mg
Yield: 94%
Reaction Conditions:
with sulfuric acid at 90; for 16 h;
Steps:
10
Reference Example 10; methyl 2-fluoro-4-hydroxybenzoate A solution of 2-fluoro-4-hydroxybenzoic acid (50.0 g) and concentrated sulfuric acid (10 mL) in methanol (700 mL) was stirred at 90°C for 16 hr with heating. The reaction solution was concentrated, and the resulting colorless crystals were washed with water, and dried to give the title compound (51 g, yield 94%) as colorless crystals. 1H NMR (300 MHz, DMSO-d6) 5: 3.79 (3 H, s), 6.61 - 6.72 (2 H, m), 7. 73 - 7.79 (1 H, m), 10.80 (1 H, br).
References:
Takeda Pharmaceutical Company Limited EP2392573, 2011, A1 Location in patent:Page/Page column 39
179232-29-2
248 suppliers
$9.00/5g
197507-22-5
114 suppliers
$6.00/100mg
65145-13-3
194 suppliers
$10.00/1g
197507-22-5
114 suppliers
$6.00/100mg
65145-13-3
194 suppliers
$10.00/1g
18107-18-1
209 suppliers
$33.00/5g
197507-22-5
114 suppliers
$6.00/100mg
331-64-6
266 suppliers
$14.00/1g
197507-22-5
114 suppliers
$6.00/100mg