Methyl 2-iodobenzoate synthesis
- Product Name:Methyl 2-iodobenzoate
- CAS Number:610-97-9
- Molecular formula:C8H7IO2
- Molecular Weight:262.04
Yield:610-97-9 99%
Reaction Conditions:
with sulfuric acid at 80; for 2.5 h;Inert atmosphere;
Steps:
1 Synthesis of 4'-acetylbiphenyl-2-carboxylic acid (1d)
Stirrer in 500 mL eggplant type flask,2-Iodobenzoic acid (13.1 g, 52.9 mmoll),After adding methanol (300 mL) and slowly adding concentrated sulfuric acid (30 mL) at room temperature,The mixture was heated and stirred at 80 ° C. for 2.5 hours under nitrogen.After the reaction is completed, cool to room temperature,Extraction was performed once with diethyl ether.The obtained organic layer was washed twice with water, once with a saturated aqueous solution of sodium hydrogen carbonate and once with a saline solution, and then washed.After adding sodium sulfate and drying, this is filtered,A crude product was obtained by concentration under reduced pressure.This was purified by silica gel column chromatography (hexane / ethyl acetate = 5/1) to obtain methyl 2-iodobenzoate (13.7 g, yield 99%).
References:
Taoka Chemical Co., Ltd.;Osaka Prefecture University.;Yanagi, Ryu;Fukuyama, Takahide;Maetani, Shinchi JP5905496, 2016, B2 Location in patent:Paragraph 0028
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