一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List METHYL 4-FORMYL-3-HYDROXYBENZOATE
24589-98-8

METHYL 4-FORMYL-3-HYDROXYBENZOATE synthesis

13synthesis methods
Methanol

67-56-1

4-FORMYL-3-HYDROXYBENZOIC ACID

619-12-5

METHYL 4-FORMYL-3-HYDROXYBENZOATE

24589-98-8

Step 1: Synthesis of methyl 4-formyl-3-hydroxybenzoate (239) 4-Formyl-3-hydroxybenzoic acid (1.2 g, 7.22 mmol) was dissolved in methanol (10 ml). Sulfoxide chloride (1.054 ml, 14.45 mmol) was added slowly and the reaction mixture was stirred at 60 °C for 3 h to ensure complete reaction. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The crude product was ground with hexane and subsequently filtered to afford methyl 4-formyl-3-hydroxybenzoate (1.3 g, 7.22 mmol, 100% yield) as a white solid. Mass spectrometric analysis (MS/ESI+) showed the molecular ion peak m/z 181.04 [MH]+.

-

Yield: 80%

Reaction Conditions:

with triethylamine;magnesium chloride in acetonitrile at 0 - 80; for 12 h;Inert atmosphere;Reagent/catalyst;Temperature;

Steps:

1-5 Example 1
Under the protection of inert gas,Compound 1 (methyl 3-hydroxybenzoate) (300g, 1.97mol, 1eq)Add to acetonitrile (4.5L),When the temperature drops to 0 ,At this temperature, 3 equivalents of anhydrous magnesium chloride (564 g, 5.92 mol, 3 eq) were slowly added in portions;When done,Continue to add triethylamine (995g, 9.85mol, 5eq) to the reaction solution in batches at this temperature;When done,Add paraformaldehyde (354g, 11.8mol, 6eq) to the reaction solution in batches at this temperature.After the addition was completed, the temperature was raised to 80 ° C., and the reaction was completed for 12 hours to obtain a reaction solution.The reaction solution was cooled to room temperature, and ethyl acetate (3 L) was added, followed by stirring for 0.5 hours.The reaction solution was poured into a 3M aqueous hydrochloric acid (4L) solution, and the layers were separated.The layers were separated and extracted twice with ethyl acetate (1 L * 2). The organic phases were combined, washed with water, and dried.EA beating and filtering to obtain 283 g of product (yield: 80%, purity 97%)

References:

Shanghai Bide Pharmaceutical Technology Co., Ltd.;Mi Taoran;Tu Qiang CN110407697, 2019, A Location in patent:Paragraph 0039-0054

METHYL 4-FORMYL-3-HYDROXYBENZOATE Related Search:

余姚市| 济阳县| 眉山市| 南乐县| 台江县| 如东县| 竹溪县| 织金县| 莆田市| 吉安市| 六枝特区| 大庆市| 通山县| 利川市| 高密市| 桦川县| 塔河县| 达日县| 丽江市| 大方县| 南漳县| 滦南县| 芒康县| 萨迦县| 渝中区| 福州市| 右玉县| 佛教| 浮梁县| 内丘县| 晋江市| 崇礼县| 芦溪县| 象州县| 津南区| 永兴县| 广平县| 昌邑市| 册亨县| 乌鲁木齐市| 勐海县|