一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List METHYL 4-FORMYL-3-HYDROXYBENZOATE
24589-98-8

METHYL 4-FORMYL-3-HYDROXYBENZOATE synthesis

13synthesis methods
Methanol

67-56-1

4-FORMYL-3-HYDROXYBENZOIC ACID

619-12-5

METHYL 4-FORMYL-3-HYDROXYBENZOATE

24589-98-8

Step 1: Synthesis of methyl 4-formyl-3-hydroxybenzoate (239) 4-Formyl-3-hydroxybenzoic acid (1.2 g, 7.22 mmol) was dissolved in methanol (10 ml). Sulfoxide chloride (1.054 ml, 14.45 mmol) was added slowly and the reaction mixture was stirred at 60 °C for 3 h to ensure complete reaction. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The crude product was ground with hexane and subsequently filtered to afford methyl 4-formyl-3-hydroxybenzoate (1.3 g, 7.22 mmol, 100% yield) as a white solid. Mass spectrometric analysis (MS/ESI+) showed the molecular ion peak m/z 181.04 [MH]+.

-

Yield: 80%

Reaction Conditions:

with triethylamine;magnesium chloride in acetonitrile at 0 - 80; for 12 h;Inert atmosphere;Reagent/catalyst;Temperature;

Steps:

1-5 Example 1
Under the protection of inert gas,Compound 1 (methyl 3-hydroxybenzoate) (300g, 1.97mol, 1eq)Add to acetonitrile (4.5L),When the temperature drops to 0 ,At this temperature, 3 equivalents of anhydrous magnesium chloride (564 g, 5.92 mol, 3 eq) were slowly added in portions;When done,Continue to add triethylamine (995g, 9.85mol, 5eq) to the reaction solution in batches at this temperature;When done,Add paraformaldehyde (354g, 11.8mol, 6eq) to the reaction solution in batches at this temperature.After the addition was completed, the temperature was raised to 80 ° C., and the reaction was completed for 12 hours to obtain a reaction solution.The reaction solution was cooled to room temperature, and ethyl acetate (3 L) was added, followed by stirring for 0.5 hours.The reaction solution was poured into a 3M aqueous hydrochloric acid (4L) solution, and the layers were separated.The layers were separated and extracted twice with ethyl acetate (1 L * 2). The organic phases were combined, washed with water, and dried.EA beating and filtering to obtain 283 g of product (yield: 80%, purity 97%)

References:

Shanghai Bide Pharmaceutical Technology Co., Ltd.;Mi Taoran;Tu Qiang CN110407697, 2019, A Location in patent:Paragraph 0039-0054

METHYL 4-FORMYL-3-HYDROXYBENZOATE Related Search:

临漳县| 江永县| 北安市| 伊金霍洛旗| 临潭县| 乌兰察布市| 乐东| 太白县| 塔城市| 民县| 丰县| 彰化县| 茶陵县| 宁陵县| 南城县| 阳山县| 临安市| 苗栗市| 大方县| 育儿| 桃园市| 嘉义县| 吴堡县| 湟源县| 临潭县| 水城县| 博爱县| 苏州市| 阜平县| 芷江| 凯里市| 将乐县| 太原市| 北辰区| 九龙县| 大宁县| 平利县| 上饶县| 凤冈县| 舟山市| 清丰县|