一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Momelotinib
1056634-68-4

Momelotinib synthesis

13synthesis methods

Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Phase 3.  It was prepared from 5-1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride with benzotriazol-1-ol by stirring DMF for overnight at room temperature.

945749-71-3 Synthesis
4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoic acid

945749-71-3
49 suppliers
inquiry

6011-14-9 Synthesis
Aminoacetonitrile hydrochloride

6011-14-9
382 suppliers
$5.00/10g

-

Yield:1056634-68-4 90%

Reaction Conditions:

with benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;triethylamine in N,N-dimethyl-formamide at 20;

Steps:

Synthesis of N-(cyanomethyl)-4-{2-[(4-morpholinophenyl)amino]pyrimidin-4-yl}benzamide (momelotinib)
Et3N (4.1 mL, 30 mmol) was added to a mixture of compound 6(1.88 g, 5.0 mmol) in DMF (20 mL). Then aminoacetonitrile hydrochloride (0.93 g, 10 mmol) was added followed by N-hydroxybenzotriazole (HOBt, 0.81 g, 6.0 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI, 1.1 g, 6.0 mmol). The mixture was stirred overnight at room temperature. After removing the solvents under reduced pressure, the residue was dissolved in CH2Cl2 (100 mL) and washed with NaHCO3 aqueous solution. The organic phase was dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure. The residue was purified by column chromatography on 200-300 mesh silica with EtOAc to afford momelotinib as: Yellow solid; yield 1.86 g (90%); m.p. 232-234 °C (lit.14 238-243 °C); IR: 3365, 3282, 1660, 1596, 1576, 1512, 1456, 1232 cm-1. Anal. calcd for C23H22N6O2: C, 66.65; H, 5.35; N, 20.28; found: C, 66.78; H, 5.49; N, 20.39%. ESI-MS: 415.1 [M + H]+, 437.1 [M + Na]+, 413.2 [M - H]-; 1H NMR (300 MHz, DMSO-d6): δ 9.47 (s, 1H), 9.32 (t, J = 5.4 Hz, 1H), 8.54 (d, J = 5.1 Hz, 1H), 8.27 (d,J = 8.1 Hz, 2H), 8.03 (d, J = 8.1 Hz, 2H), 7.67 (d, J = 8.7 Hz, 2H), 7.40 (d, J = 5.1 Hz, 1H), 6.94 (d, J = 8.7 Hz, 2H), 4.35 (d, J = 5.1 Hz, 2H), 3.74-3.77 (m, 4H), 3.04-3.07 (m, 4H); 13C NMR (75 MHz, DMSO-d6): δ 166.1, 162.4, 160.3, 159.2, 146.2, 139.9, 134.5, 132.8, 127.8, 126.9, 120.3, 117.5, 115.6, 107.6, 66.1, 49.2, 27.7.

References:

Sun, Tong;Xu, Jiaojiao;Ji, Min;Wang, Peng [Journal of Chemical Research,2016,vol. 40,# 8,p. 511 - 513]

FullText

Momelotinib Related Search:

集贤县| 嘉鱼县| 乌拉特中旗| 麦盖提县| 阿拉尔市| 土默特右旗| 辽阳县| 清丰县| 即墨市| 大新县| 东丰县| 玛多县| 宁蒗| 图们市| 龙山县| 调兵山市| 洱源县| 宁安市| 牟定县| 长岛县| 乌恰县| 潜山县| 博爱县| 宿州市| 寻乌县| 广水市| 兴业县| 年辖:市辖区| 闵行区| 建始县| 平湖市| 新邵县| 中方县| 桓台县| 尤溪县| 城步| 休宁县| 抚宁县| 博客| 疏勒县| 福州市|