N-2-HYDROXYETHYL-M-TOLUIDINE synthesis
- Product Name:N-2-HYDROXYETHYL-M-TOLUIDINE
- CAS Number:102-41-0
- Molecular formula:C9H13NO
- Molecular Weight:151.21
Yield:102-41-0 92%
Reaction Conditions:
with copper(l) chloride;potassium hydroxide at 20; for 8 h;Neat (no solvent);
Steps:
General Procedure A: Cu-catalyzed N-arylation of amino alcohols with iodobenzenes
General Procedure: CuCl (10 mg, 0.1 mmol), Aryl iodided (if solid, 1.0 mmol), and KOH (112 mg, 2.0 mmol) were added to a screw-capped test tube. Aryl iodided (if liquid, 1.0 mmol), and amino alcohol (3 mmol) were added by syringe at room temperature. The reaction mixture was stirred at room temperature for 8-12h. The resulting mixture was diluted with water (2 mL) before extraction with ethyl acetate (410 mL), and dried over Na2SO4, the filtrate was concentrated under reduced pressure, and the mixture was purified by column chromatography on silica gel to afford the desired product.
References:
Yin, Huiqing;Jin, Ming;Chen, Wei;Chen, Chen;Zheng, Likang;Wei, Ping;Han, Shiqing [Tetrahedron Letters,2012,vol. 53,# 10,p. 1265 - 1270] Location in patent:supporting information; experimental part
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