N-BUTYLISOCYANIDE synthesis
- Product Name:N-BUTYLISOCYANIDE
- CAS Number:2769-64-4
- Molecular formula:C5H9N
- Molecular Weight:83.13
Yield:-
Reaction Conditions:
with tetra(n-butyl)ammonium hydrogensulfate;sodium hydroxide in dichloromethane;water for 12 h;Inert atmosphere;
Steps:
4.2.1. General procedure for isocyanide synthesis
General procedure: Naphthyl isocyanides and 3-isocyanoquinoline were prepared following literature reported procedures.refPreviewPlaceHolder29 To a well stirred solution of the amine (2.6 mmol) in CH2Cl2 (1.5 mL) and CHCl3 containing n-Bu4NHSO4 (90 mg; 0.26 mmol) was added in one portion 50% aqueous NaOH (1.5 mL). The reaction mixture was stirred for 12 h, then diluted with water and extracted with CHCl3. The combined extracts were dried over MgSO4 and concentrated in vacuo. Products were purified by column chromatography with DCM as the mobile phase.
References:
Okandeji, Babajide O.;Greenwald, Daniel M.;Wroten, Jessica;Sello, Jason K. [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 24,p. 7679 - 7689] Location in patent:experimental part
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