N-CHLOROACETYLGLYCINE synthesis
- Product Name:N-CHLOROACETYLGLYCINE
- CAS Number:6319-96-6
- Molecular formula:C4H6ClNO3
- Molecular Weight:151.55
79-04-9
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6319-96-6
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Yield:6319-96-6 84%
Reaction Conditions:
in sodium hydroxide;diethyl ether
Steps:
64.A A.
A. Chloroacetyl glycine Glycine (1.5 g, 20 mmol) was dissolved in 2N NaOH (25 ml, 50 mmol) and ether (20 ml) was added. Chloroacetyl chloride (2.26 g) dissolved in Et2 O (20 ml) was added dropwise at 0° C. The mixture was stirred at 0° for 30 minutes and at room temperature 1 hour. The layers were separated and the water layer was washed with Et2 O (2*20 ml). The water layer was then acidified to pH 2 with concentrated HCl and the product was extracted into EtOAc (3*50 ml). The combined EtOAc extracts were washed with brine, dried (MgSO4), and freed of solvent in vacuo to give title acid compound as a solid (2.56 g, 84%) which was used without further purification.
References:
E. R. Squibb & Sons, Inc. US4663336, 1987, A E. R. Squibb & Sons, Inc. US4734424, 1988, A
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6319-96-6
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6319-96-6
94 suppliers
$33.39/250mg