N-Ethylmaleimide synthesis
- Product Name:N-Ethylmaleimide
- CAS Number:128-53-0
- Molecular formula:C6H7NO2
- Molecular Weight:125.13
108-31-6
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$13.47/50 G
557-66-4
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$25.00/25g
128-53-0
286 suppliers
$5.00/250mg
Yield:-
Reaction Conditions:
with potassium acetate;acetic acid at 110; for 4 h;
Steps:
Step 1
General procedure: Methylamine hydrochloride (19.1 g, 0.30 moles) was added to a solution of acetic acid (40 ml), maleic anhydride (20 g, 0.20 moles) and potassium acetate (30.0 g, 0.30 moles) and the mass was stirred for 4 hrs at reflux temperature (110 oC). After completion of reaction, the mass was cooled to 25 - 30 oC. The reaction mass was poured, slowly, on to the chilled sodium bicarbonate solution (100 ml) and the product was extracted with diethylether (3 x 70 ml). The organic layer was washed with brine solution, dried over anhydrous sodium sulfate and solvent was removed under reduced pressure to afford 1-methyl pyrrole-2,5-dione (6.89 g, 30 %).
References:
Nirogi, Ramakrishna;Dwarampudi, Adireddy;Kambhampati, Ramasastry;Bhatta, Venugopalarao;Kota, Laxman;Shinde, Anil;Badange, Rajesh;Jayarajan, Pradeep;Bhyrapuneni, Gopinadh;Dubey [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 15,p. 4577 - 4580] Location in patent:supporting information; experimental part
109-96-6
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74-96-4
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128-53-0
286 suppliers
$5.00/250mg
108-31-6
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$13.47/50 G
75-04-7
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$10.00/20mg
128-53-0
286 suppliers
$5.00/250mg
4166-67-0
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$56.10/10g
128-53-0
286 suppliers
$5.00/250mg
128438-93-7
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$139.00/50mg
128-53-0
286 suppliers
$5.00/250mg