N-Isopropylaniline synthesis
- Product Name:N-Isopropylaniline
- CAS Number:768-52-5
- Molecular formula:C9H13N
- Molecular Weight:135.21
Yield:768-52-5 96.2%
Reaction Conditions:
with copper(l) chloride;sodium hydroxide in water at 95; for 6.5 h;Autoclave;Sealed tube;Temperature;
Steps:
1-3 Example 3 Synthesis of N-isopropylaniline
Put 500ml water and 70g flake caustic soda (molecular weight 40, 1.77mol) into a 1000ml autoclaveStir thoroughly and dissolve for 10 minutes, then put in 222g bromobenzene (molecular weight 157, 1.4mol),70g isopropylamine (molecular weight: 59.1, 1.18mol), 2g cuprous chloride (molecular weight: 99, 0.02mol), then sealed and stirred for 30 minutes, heated to 95°C for 1 hour and kept for 5 hours to detect the end point.After the end point is reached, the temperature is reduced to 80°C, the pressure is relieved and the material is filtered,Wash with hot water above 80°C to neutrality, and dry the filter cake for later use.The content is 98.7percent and the yield is 96.2percent.
References:
Jiangsu Daobo Chemical Co., Ltd.;Jiang Weiqiang;He Zhenrong;Wu Xinmin;Chen Luyun CN111518409, 2020, A Location in patent:Paragraph 0023-0031
