N,N-DIMETHYLHEXYLAMINE synthesis
- Product Name:N,N-DIMETHYLHEXYLAMINE
- CAS Number:4385-04-0
- Molecular formula:C8H19N
- Molecular Weight:129.24
111-25-1
322 suppliers
$10.00/5g
124-40-3
541 suppliers
$18.00/100ml
4385-04-0
89 suppliers
$37.20/5g
Yield: 70%
Reaction Conditions:
with sodium hydroxide in water;toluene for 72 h;Autoclave;
Steps:
Alkyldimethylamines 8a-c
General procedure: Bromoalkanes 7 (bromohexane (7a) 2.3 mol; bromooctane(7b) 1.9 mol; bromodecane (7c) 1.6 mol; 1 eq)were mixed with toluene (300 mL) in a 3 L autoclave. Then40% N,N-dimethylamine (6) solution in water (500 mL,approx. 2 eq) was added. An excess amount of NaOH (200mL) was added as a 50% aqueous solution. The mixtureswere stirred and heated to 60 °C for 3 days. After the reactionwas completed the reaction mixture separated in twolayers. The organic phase containing products was separatedfrom water phase and concentrated under reducedpressure. The products were washed several times with water(5 × 20 mL) and distilled under reduced pressure toensure separation from inorganic byproducts and to removetoluene (8a 70%, 8b 90%, 8c 95%). While amine 8ccan be dried on a vacuum line with minimal loss due toevaporation, the distillation results in better overall yield.The presence of toluene in product is not problematic, as itis removed in the following steps.
References:
?tanfel, Ur?a;?ener, Bo?tjan;Be?ter-Roga?, Marija;Ko?mrlj, Janez;Medo?, ?iga;Virant, Miha [Acta Chimica Slovenica,2020,vol. 67,# 1,p. 270 - 275]
5830-30-8
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$31.30/5g
4385-04-0
89 suppliers
$37.20/5g
111-26-2
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$10.00/5g
4385-04-0
89 suppliers
$37.20/5g
109-67-1
184 suppliers
$35.00/25 g
201230-82-2
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124-40-3
541 suppliers
$18.00/100ml
4385-04-0
89 suppliers
$37.20/5g