N6-Cbz-L-Lysine synthesis
- Product Name:N6-Cbz-L-Lysine
- CAS Number:1155-64-2
- Molecular formula:C14H20N2O4
- Molecular Weight:280.32
Yield:1155-64-2 80%
Reaction Conditions:
Stage #1:L-lysine with L-serin;L-leucine;β‐cyclodextrin in aq. buffer; pH=8 at 20; for 0.0833333 h;
Stage #2:benzyl chloroformate in aq. buffer at 20;chemoselective reaction;Reagent/catalyst;
Steps:
General procedure: β-Cyclodextrin (0.1 mmol) was dissolved in 0.1 M carbonate buffer (pH = 8)(10 mL) at room temperature, the L-lysine (1 mmol) and other amino acids (1 mmol)were added, and the reaction mixture was stirred for 5 min. Cbz-Cl (1 mmol) wasadded and stirring was continued at room temperature until the reaction was complete.The reaction mixture was extracted with ethyl acetate (2 × 5 ml). The solvent wasremoved under vacuum and the products were obtained.
References:
Su, Jie;Su, Fan;Ma, MingFang;Li, Shangyang;Xing, Pengyao;Hao, Aiyou [Synthetic Communications,2014,vol. 44,# 8,p. 1111 - 1121]
![L-Lysine, N2-[[(4-methoxyphenyl)methoxy]carbonyl]-N6-[(phenylmethoxy)carbonyl]-](/CAS/20210305/GIF/42533-12-0.gif)
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