Naphazoline synthesis
- Product Name:Naphazoline
- CAS Number:835-31-4
- Molecular formula:C14H14N2
- Molecular Weight:210.27
Yield:835-31-4 85%
Reaction Conditions:
for 2 h;Reflux;Time;
Steps:
1-2
In a three-necked flask, add quantitative α-naphthaleneacetic acid and ethylenediamine, several grains of anti-riot agent, and put them in the heating mantle.Increase the temperature and reflux, and recover the ethylenediamine after refluxing for 2 hours. Transfer the reactant to another three-necked flask, add the anti-riot agent, and distill under reduced pressureCollect the base (ie crude naphazoline) and weigh to obtain Intermediate 1. The yield of Intermediate 1 is 85%.
References:
Shanxi Liye Pharmaceutical Co., Ltd.;Yue Wang;Cui Jianlan;Gao Yanhong;Ma Liang;Liang Guangqi CN112209880, 2021, A Location in patent:Paragraph 0015; 0018-0019
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