Oleanolic acid benzoate synthesis
- Product Name:Oleanolic acid benzoate
- CAS Number:6153-31-7
- Molecular formula:C37H52O4
- Molecular Weight:560.81
Yield:6153-31-7 72%
Reaction Conditions:
Stage #1: Oleanolic acidwith triethylamine in dichloromethane at 0; for 0.5 h;
Stage #2: benzoyl chloride in dichloromethane at 30;Microwave irradiation;Temperature;
Steps:
4.1.4. General procedure for synthesis of compounds 1, 3, 5 and 6
General procedure: To a well stirred and cooled at 0 °C solution of OA (1.0 equiv.) in dry CH2Cl2 was added dropwise 2.1 equiv. of Et3N. Mixture reaction was stirred at 0 °C for 30 min. Acyl chloride (1.1 equiv.) was added dropwise over a period of 5 min, then mixture reaction was placed under microwave radiation in equipment CEM at 30° C. Solvent was concentrated under vacuum and de crude reaction was purified by FCC.
References:
Ramírez-Espinosa, Juan José;Rios, Maria Yolanda;Paoli, Paolo;Flores-Morales, Virginia;Camici, Guido;Rosa-Lugo, Vianey De La;Hidalgo-Figueroa, Sergio;Navarrete-Vázquez, Gabriel;Estrada-Soto, Samuel [European Journal of Medicinal Chemistry,2014,vol. 87,p. 316 - 327]
