p-Toluoyl chloride synthesis
- Product Name:p-Toluoyl chloride
- CAS Number:874-60-2
- Molecular formula:C8H7ClO
- Molecular Weight:154.59
99-94-5
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$9.00/1g
874-60-2
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$10.00/5g
Yield:874-60-2 100%
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 35; for 1 h;
Steps:
Syntheses of Aryl Acid Chlorides (4a-f)
General procedure: The reaction scheme for the syntheses of aryl acid chlorides (4a-f) is shown in Scheme (1). Into a 250 mL two neck round bottomed flask equipped with a mechanical stirrer and a dropping funnel was placed in a thermostat bath. To a stirred solution of aryl acid (3a-f) 8 mM (3a: 0.98 g; 3b: 1.22g; 3c: 1.09 g; 3d: 1.34 g; 3e: 1.34 g; 3f: 1.18 g) in 100 mL CH2Cl2 at room temperature was added 16 mM (2.02 g) oxalyl chloride, 2 drops of DMF and the mixture was stirred at room temperature for 1h. The resulting mixture was concentrated under reduced pressure to afford acid chloride quantitatively and stored in air tight flask.
References:
Patel, Chirag Bhupendra;Dhaduk, Bhavin Babu;Parsania, Parsotam Hari [Letters in drug design and discovery,2015,vol. 12,# 6,p. 505 - 511]
13756-42-8
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$7.00/1g
874-60-2
423 suppliers
$10.00/5g
106-42-3
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$18.00/25ML
874-60-2
423 suppliers
$10.00/5g
100-20-9
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$14.00/25g
104-87-0
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$6.00/25g
874-60-2
423 suppliers
$10.00/5g
589-18-4
320 suppliers
$5.00/5g
874-60-2
423 suppliers
$10.00/5g