Phlorisovalerophenone synthesis
- Product Name:Phlorisovalerophenone
- CAS Number:26103-97-9
- Molecular formula:C11H14O4
- Molecular Weight:210.23
Yield:26103-97-9 90%
Reaction Conditions:
with Aluminum Chloride in nitromethane at 40; for 5 h;
Steps:
1.1 The first step:
At room temperature, dissolve phloroglucinol 5 in a nitromethane solution, add anhydrous aluminum trichloride and isovaleryl chloride successively, and heat to 40 C.After reacting for 5 hours, slowly pour the reaction solution into ice water, add saturated potassium sodium tartrate solution, and stir vigorously.The reaction solution was extracted 3 times with ethyl acetate.The organic phases were combined and washed with saturated NaCl solution.After drying and filtering with anhydrous sodium sulfate, the organic phase was evaporated to dryness under reduced pressure.The resulting crude product was separated and purified by silica gel column chromatography to obtain compound 7 (90% yield)
References:
CN112125920,2020,A Location in patent:Paragraph 0027
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