PHYSOSTIGMINE synthesis
- Product Name:PHYSOSTIGMINE
- CAS Number:57-47-6
- Molecular formula:C15H21N3O2
- Molecular Weight:275.35
![2-Butenoic acid, 2-methyl-4-[[tris(1-methylethyl)silyl]oxy]-, (2Z)-](/CAS/20210111/GIF/153109-50-3.gif)
153109-50-3
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Yield:-
Steps:
Multi-step reaction with 6 steps
1: 55 percent / DCC, HOBT / tetrahydrofuran / Heating
2: 94 percent / Pd2(dba)3*CHCl3, (S)-BINAP, 1,2,2,6,6-pentamethylpiperidine / N,N-dimethyl-acetamide / 1.5 h / 100 °C
3: 80 percent / 3M aq. HCl / tetrahydrofuran / Ambient temperature
4: 1.) Et3N, MgSO4, 2.) LiAlH4 / 1.) THF, RT, overnight, 2.) THF, reflux, 1.5 h
5: BBr3 / CH2Cl2 / 23 °C
6: NaH / diethyl ether
References:
Matsuura, Takaharu;Overman, Larry E.;Poon, Daniel J. [Journal of the American Chemical Society,1998,vol. 120,# 26,p. 6500 - 6503]
![2-Butenamide, N-(2-iodo-4-methoxyphenyl)-N,2-dimethyl-4-[[tris(1-methylethyl)silyl]oxy]-, (2Z)-](/CAS/20210305/GIF/153109-51-4.gif)
153109-51-4
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57-47-6
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153109-52-5
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57-47-6
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![2H-Indol-2-one, 1,3-dihydro-5-methoxy-1,3-dimethyl-3-[(1E)-2-[[tris(1-methylethyl)silyl]oxy]ethenyl]-, (3S)-](/CAS/20210305/GIF/153109-54-7.gif)
153109-54-7
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57-47-6
134 suppliers
$25.00/10mg