ChemicalBook CAS DataBase List PLERIXAFOR

PLERIXAFOR synthesis

5synthesis methods

Product Name:PLERIXAFOR
CAS Number:110078-46-1
Molecular formula:C28H54N8
Molecular Weight:502.78

Plerixafor can be synthesized by several related procedures starting from tetraazacyclotetradecane, the macrocyclic tetraamine cyclam. The general synthetic strategy entails the masking of three of the four ring nitrogens, followed by alkylation with para-xylylene dibromide, and subsequent removal of the masking groups. In one approach, tetraazacyclotetradecane is protected as the phosphorotriamide derivative by reaction with tris (dimethylamino)phosphine followed by oxidation with carbon tetrachloride and sodium hydroxide. After condensation with xylylene dibromide, the dimeric bis-phosphoramide intermediate is hydrolyzed to plerixafor by treatment with dilute hydrochloric acid solution.

623-24-5 Synthesis

623-24-5
313 suppliers
$6.00/1g

110078-46-1
284 suppliers
$19.00/5mg

1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylMethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone

406939-93-3
15 suppliers
$160.00/2.5mg

110078-46-1
284 suppliers
$19.00/5mg

References

592516-98-8
2 suppliers
inquiry

110078-46-1
284 suppliers
$19.00/5mg

References

623-24-5 Synthesis

623-24-5
313 suppliers
$6.00/1g

295-37-4 Synthesis

295-37-4
314 suppliers
$18.00/250mg

110078-46-1
284 suppliers
$19.00/5mg

References

1,4,8,11-Tetraazacyclotetradecane-1,4,8-tricarboxylic acid, 11,11'-[1,4-phenylenebis(methylene)]bis-, hexakis(1,1-dimethylethyl) ester (9CI)

175854-48-5
1 suppliers
inquiry

110078-46-1
284 suppliers
$19.00/5mg

References

PLERIXAFOR Related Search:

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PLERIXAFOR synthesis

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