Pregnenolone synthesis
- Product Name:Pregnenolone
- CAS Number:145-13-1
- Molecular formula:C21H32O2
- Molecular Weight:316.48
58701-45-4
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$120.00/5mg
145-13-1
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$28.00/500mg
Yield:145-13-1 97%
Reaction Conditions:
with chloro-methylsulfanyl-methane;water;potassium iodide in 1,4-dioxane at 50; for 3.3 h;
Steps:
Deprotection of silyl ethers; the desilylation of 1a
General procedure: Protected diosgenin 1a (200 mg, 1 equiv.), chloromethyl methyl sulfide (4 mg, 0.1 equiv.), KI (2 mg, 0.03 equiv.), dioxane (4.0 mL)and water (102 mg, 15 equiv.) were added to a 25 mL round-bottom flask. The mixture was then stirred at 50 °C for 2.3 h. The solvent was then removed under reduced pressure for silica gel chromatography to furnish diosgenin 1aa as: White solid; yield 152 mg (>99%).
References:
Niu, Qun;Xing, Linlin;Li, Chunbao [Journal of Chemical Research,2017,vol. 41,# 6,p. 358 - 364]
979-02-2
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$20.00/100mg
145-13-1
507 suppliers
$28.00/500mg
1778-02-5
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$12.00/1mg
145-13-1
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$28.00/500mg
516-72-3
98 suppliers
$44.00/1mg
145-13-1
507 suppliers
$28.00/500mg
83-46-5
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$5.00/250mg
145-13-1
507 suppliers
$28.00/500mg