Quinine synthesis
- Product Name:Quinine
- CAS Number:130-95-0
- Molecular formula:C20H24N2O2
- Molecular Weight:324.42
5263-87-6
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130-95-0
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Yield:130-95-0 140 mg (26%)
Reaction Conditions:
in s-BuOH;
Steps:
Experimental Data
Data for 3-H: see above. (2S,5R,9R/S)-2-(t-Butoxycarbonyloxymethyl)-9-deuterio-5-ethenyl-1-azabicyclo(2.2.2)octane (7a+7b) and 4-deuterio-6-methoxyquinoline (3-D). Reducing agent: LiAlD4, secondary alcohol: s-BuOH (0.55 ml, 6 mmol), cinchona alkaloid: quinine, yield: 140 mg (26%) of 7a+7b (43% d.e.) and 119 mg (37%) of 3-D.
References:
US5777122,1998,A
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865853-18-5
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130-95-0
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865853-24-3
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130-95-0
446 suppliers
$6.00/1g