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ChemicalBook CAS DataBase List (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol
14347-78-5

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol synthesis

9synthesis methods
Using anhydrous zinc chloride as the catalyst, the condensation reaction of D-mannitol with acetone to synthesize the diisopropylidene condensate was carried out under the optimal reaction conditions, with a yield of up to 65%. Subsequently, (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol was obtained via chain cleavage by NaIO? oxidation and reduction with NaBH?.
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 91 percent / DMAP, Na2CO3 / ethyl acetate
2: H2O, Rhizopus oryzae lipase, BES buffer (pH 7.2), Triton X-100 / 16.5 h / 25 °C / different time; various hydrolases

References:

Janes, Lana E.;Loewendahl, A. Christina;Kazlauskas, Romas J. [Chemistry - A European Journal,1998,vol. 4,# 11,p. 2324 - 2331]

FullText

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