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ChemicalBook CAS DataBase List Sitagliptin Defuoro IMpurity 3
851307-12-5

Sitagliptin Defuoro IMpurity 3 synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 8 steps
1: (COCl)2; DMF / CH2Cl2
2: 2,4,6-collidine
3: 81 percent / 4 h / Heating
4: 87 percent / AcOH / methanol / 2 h / 40 °C
5: 42 percent / H2 / PtO2 / tetrahydrofuran; methanol / 4654.46 Torr
6: AcOH / Pearlman's catalyst / methanol; H2O
7: Et3N / CH2Cl2
8: 87 percent / aq. LiOH / tetrahydrofuran

References:

Kim, Dooseop;Kowalchick, Jennifer E.;Edmondson, Scott D.;Mastracchio, Anthony;Xu, Jinyou;Eiermann, George J.;Leiting, Barbara;Wu, Joseph K.;Pryor, KellyAnn D.;Patel, Reshma A.;He, Huaibing;Lyons, Kathryn A.;Thornberry, Nancy A.;Weber, Ann E. [Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,# 12,p. 3373 - 3377]

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