ChemicalBook CAS DataBase List Ethyl trifluoroacetate

Ethyl trifluoroacetate synthesis

15synthesis methods

Product Name:Ethyl trifluoroacetate
CAS Number:383-63-1
Molecular formula:C4H5F3O2
Molecular Weight:142.08

Trifluoroacetic acid and ethanol were used as starting materials with strong-acid cation exchange resin as catalysts at 40 ~ 50 she℃. Add ethanol drop and temperature rising reflux divides the mixture of water and ethanol. After that, collect the mix of thick product ethanol and Ethyl trifluoroacetate. The crude product collected is added a small amount of water, and layering can obtain a content of more than 99.5%. The qualified product Ethyl trifluoroacetate, whose moisture is less than 0.1%, yields more than 95%.

354-32-5
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64-17-5 Synthesis

64-17-5
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383-63-1
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$10.00/25g

Yield:383-63-1 97.86%

Reaction Conditions:

at 35 - 58; for 1 h;Temperature;

Steps:

4 Example 4

The reactor was a three-necked flask having a volume of 250 ml,With stirring,thermometer,Airway and rectification column,The rectification column is connected to a condenser and a HCl absorption device.88 g of ethanol was added to the reactor,After the temperature had risen to 35 ° C, trifluoroacetyl chloride gas was introduced,The trifluoroacetyl chloride was fed at a feed rate of 2 g / min.After reaction at 35 ° C for 60 min,The ethanolic liquid was started to drop,The dropping rate of ethanol was 0.31 g / min,The temperature was gradually increased to 58 ° C,Distillation of ethyl trifluoroacetate was carried out by reactive distillation,The hydrogen chloride gas was absorbed by the HCl absorption device,Generation by-product hydrochloric acid.Reaction distillation for 160min to obtain distillation products 425.7g,Chromatographic analysis of the purity of ethyl trifluoroacetate was 97.93%The yield was 97.86%.

References:

CN103864615,2016,B Location in patent:Paragraph 0039; 0040

64-17-5 Synthesis

64-17-5
856 suppliers
$10.00/50g