Ethyl trifluoroacetate
- CAS No.
- 383-63-1
- Chemical Name:
- Ethyl trifluoroacetate
- Synonyms
- ETHYL 2,2,2-TRIFLUOROACETATE;ETFA;TFAET;TRIFLUOROACETIC ACID ETHYL ESTER;CF3COOC2H5;RARECHEM AL BI 0416;Ethyltrifluoracetat;2,2,2-Trifluoroacetic acid ethyl ester;cb1020;fd06h11
- CBNumber:
- CB6349488
- Molecular Formula:
- C4H5F3O2
- Molecular Weight:
- 142.08
- MDL Number:
- MFCD00000419
- MOL File:
- 383-63-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ethyl trifluoroacetate 99% | E50000 | 25g | $36.4 |
| Ethyl trifluoroacetate 99% | E50000 | 100g | $121 |
| Ethyl Trifluoroacetate >99.0%(GC) | T0432 | 25g | $27 |
| Ethyl Trifluoroacetate >99.0%(GC) | T0432 | 100g | $81 |
| Ethyltrifluoroacetate, 99% 99% | 09-3270 | 25g | $30 |
| More product size | |||
| Melting point | -78 °C |
|---|---|
| Boiling point | 60-62 °C(lit.) |
| Density | 1.194 g/mL at 25 °C(lit.) |
| vapor pressure | 18.5kPa at 20℃ |
| refractive index |
n |
| Flash point | 30 °F |
| storage temp. | 2-8°C |
| solubility | 4g/l |
| pka | 0.43[at 20 ℃] |
| form | Liquid |
| Specific Gravity | 1.194 |
| color | Clear |
| PH | 4 (4g/l, H2O, 20℃) |
| Water Solubility | HYDROLYSIS |
| Sensitive | Moisture Sensitive |
| BRN | 1761411 |
| Henry's Law Constant | 8.9×10-4 mol/(m3Pa) at 25℃, Burkholder et al. (2019) |
| Stability | Hygroscopic, Moisture Sensitive, Volatile |
| InChI | 1S/C4H5F3O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3 |
| InChIKey | STSCVKRWJPWALQ-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C(F)(F)F |
| LogP | 0.79-1.032 at 25℃ |
| CAS DataBase Reference | 383-63-1(CAS DataBase Reference) |
| FDA UNII | A6TZK6X11X |
| NIST Chemistry Reference | Acetic acid, trifluoro-, ethyl ester(383-63-1) |
| EPA Substance Registry System | Ethyl trifluoroacetate (383-63-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H225 | |||||||||
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | F,Xn,C | |||||||||
| Risk Statements | 11-22-37/38-41-34 | |||||||||
| Safety Statements | 9-16-26-36/39-45-36/37/39 | |||||||||
| RIDADR | UN 1993 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| Hazard Note | Flammable/Corrosive | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29159080 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Flam. Liq. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 1.0 L (0.3 gallon) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Ethyl trifluoroacetate price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E50000 | Ethyl trifluoroacetate 99% | 383-63-1 | 25g | $36.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | E50000 | Ethyl trifluoroacetate 99% | 383-63-1 | 100g | $121 | 2026-04-30 | Buy |
| TCI Chemical | T0432 | Ethyl Trifluoroacetate >99.0%(GC) | 383-63-1 | 25g | $27 | 2026-04-30 | Buy |
| TCI Chemical | T0432 | Ethyl Trifluoroacetate >99.0%(GC) | 383-63-1 | 100g | $81 | 2026-04-30 | Buy |
| Strem Chemicals | 09-3270 | Ethyltrifluoroacetate, 99% 99% | 383-63-1 | 25g | $30 | 2026-04-30 | Buy |
Ethyl trifluoroacetate Chemical Properties,Uses,Production
Chemical Properties
Colorless to yellow liquid
Uses
Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of tri fluoroacylated compounds.
Uses
Widely used in the synthetic process of medicine, pesticides and organic intermediate.
Uses
Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds.
Preparation
Trifluoroacetic acid and ethanol were used as starting materials with strong-acid cation exchange resin as catalysts at 40 ~ 50 she℃. Add ethanol drop and temperature rising reflux divides the mixture of water and ethanol. After that, collect the mix of thick product ethanol and Ethyl trifluoroacetate. The crude product collected is added a small amount of water, and layering can obtain a content of more than 99.5%. The qualified product Ethyl trifluoroacetate, whose moisture is less than 0.1%, yields more than 95%.
Definition
ChEBI: TRIFLUOROACETIC ACID ETHYL ESTER is an organohalogen compound. It is functionally related to a carboxylic acid.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 3527, 1950 DOI: 10.1021/ja01164a056
Flammability and Explosibility
Highly flammable
Purification Methods
Fractionate it through a long Vigreux column (p 11). IR has max at 1800 (CO2) and 1000 (OCO) cm-1 [Fuson et al. J Chem Phys 20 1627 1952, Bergman J Org Chem 23 476 1958]. [Beilstein 2 IV 463.]
Ethyl trifluoroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Qiwei Pharmatech Co.,Ltd | 13282840061 | mw@qwpharmatech.com | China | 109 | 58 |
| Shandong Dexiang International Trade Co., Ltd | +8615662691337 | 539942812@qq.com | China | 998 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Chongqing Soarwin Technology Co., Ltd | +86-15790943001 | crystal@sorawin.cn | China | 421 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
View Lastest Price from Ethyl trifluoroacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-24 | Ethyl trifluoroacetate
383-63-1
|
1KG | 99% | 200mt | Jinan Finer Chemical Co., Ltd | ||
 |
2026-07-01 | Ethyl trifluoroacetate
383-63-1
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2026-03-20 | Ethyl trifluoroacetate
383-63-1
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Ethyl trifluoroacetate
383-63-1
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Ethyl trifluoroacetate
383-63-1
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- Ethyl trifluoroacetate
383-63-1
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
