Tandospirone citrate synthesis
- Product Name:Tandospirone citrate
- CAS Number:112457-95-1
- Molecular formula:C21H29N5O2.C6H8O7
- Molecular Weight:575.615
87760-53-0
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Yield:112457-95-1 99%
Reaction Conditions:
in diethyl ether;acetone;Heating;
Steps:
1 Example 1 Preparation of crystalline form IV of tandospirone citrate
A solution of citric acid in acetone was prepared by dissolving 41 g of citric acid in 300 mL of acetone.Weigh 80gTandospirone,Join600 mL of acetone and 300 mL of ether,Dissolved,Dropping the configured citric acid acetone solution,Heating and stirring to complete the reaction,Natural cooling to room temperature for 6h,Filtration,washing,Dried under reduced pressure,That is 118. 8gWhite powder of tandospirone citrateForm IV,The yield was 99.0%.
References:
CN105985327,2016,A Location in patent:Paragraph 0035; 0036; 0037; 0038; 0039
20980-22-7
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99095-09-7
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14166-28-0
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2746-19-2
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