ChemicalBook CAS DataBase List Sodium isethionate

Sodium isethionate synthesis

8synthesis methods

Product Name:Sodium isethionate
CAS Number:1562-00-1
Molecular formula:C2H5NaO4S
Molecular Weight:148.11

Sodium isethionate is an organic salt and an important intermediate for pharmaceuticals, cosmetics and daily chemicals. It can be synthesized by the condensation reaction of sodium bisulfite with ethylene oxide.

75-21-8
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1562-00-1
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Yield:1562-00-1 99.5%

Reaction Conditions:

with sodium hydrogen sulfate at 40; for 0.25 h;Large scale;Temperature;

Steps:

2
2006.3 g of 35 wt% sodium hydrogen sulfite solution was placed in a 10 L reaction vessel, the temperature in the autoclave was maintained at 40 ° C,and 10.5 g of Sn-beta catalyst was added to the kettle, and the mixture was uniformly mixed, and then 300 g of a ring was slowly introduced into the reaction vessel. ethylene oxide, throughafter the ethylene oxide, the reaction was continued for 30min, sample analysis, in a yield of this step is 99.7%; then added into the reactorinto a certain amount of pure water, the system isethionic the sodium concentration was diluted to around 15.0wt%, followed by a quantity of liquid ammonia into theammonia concentration of 21.0wt%, followed by addition of 2.0 g of (0.2 wt%) NH2_{. 4}BiO_{. 3}catalyst and a cocatalyst and 1.0gCuCl, thereaction system The mixture was heated to 140 ° C, the system pressure was 7.2 MPa, and the reaction was carried out for 20 min. The yield of sodium taurate obtained in this step was89.0%.After the reaction solution was flashed with ammonia at 100 ° C, concentrated by evaporation, the concentration of sodium taurate was concentrated to 38 wt%, and then thepH of the system was adjusted to 8.2 by adding a certain amount of concentrated sulfuric acidat60 ° C, followed by cooling to 30 ° C. After crystallization, theyield oftaurine per crystalwas 70.0%, and the mother liquor could be applied again to the aminolysis reaction, and the total yield of taurine after application was 90.9%.

References:

Wanhua Chemical Group Co., Ltd.;Gui Zhenyou;Zhang Jing;Guo Bin;Zhao Kaifei;Lin Haizheng;Zhong Zitai;Kong Lingxiao;Liang Jing;Wang Wen;Li Jing;Li Hao;Chen Laizhong;Zhang Yongzhen CN109485586, 2019, A Location in patent:Paragraph 0046; 0047; 0048; 0050; 0052

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107-35-7 Synthesis