Diclofenac sodium synthesis
- Product Name:Diclofenac sodium
- CAS Number:15307-79-6
- Molecular formula:C14H10Cl2NNaO2
- Molecular Weight:318.13
15307-78-5
104 suppliers
$39.00/10mg
15307-79-6
901 suppliers
$14.00/5g
Yield:15307-79-6 96.1%
Reaction Conditions:
with sodium hydroxide in water;N,N-dimethyl-formamide at 80; for 24 h;
Steps:
1.2; 2.2; 3.2 (2) Synthesis of diclofenac sodium
25 g (0.08 mol) of Compound C, 160 mL of N,N-dimethylformamide were added to a three-necked flask, and the mixture was stirred and heated to 80 °C. After adding 8g (0.2mol) of NaOH and 35g of water to form a solution, continue the reaction for 24h, After completion of the reaction, the solvent was distilled off under reduced pressure, the residue was dissolved by heating with 200mL of water, decolorized with charcoal, suction filtered, the filtrate was cooled in an ice-water bath crystallization, filtration, The white crystalline powder diclofenac sodium was dried to 24.6 g, the yield was 96.1%, and the content determined by HPLC was 98.2%. The overall yield of the above reaction was 90.5%.
References:
CN109553544,2019,A Location in patent:Paragraph 0017-0026
15362-40-0
329 suppliers
$8.00/5g
15307-79-6
901 suppliers
$14.00/5g
87-65-0
413 suppliers
$10.00/10g
35613-44-6
96 suppliers
$35.00/250mg
15307-79-6
901 suppliers
$14.00/5g
40311-72-6
16 suppliers
$437.00/1g
35613-44-6
96 suppliers
$35.00/250mg
15307-79-6
901 suppliers
$14.00/5g
2444-36-2
455 suppliers
$5.00/25g
608-31-1
309 suppliers
$12.00/25g
71-36-3
1105 suppliers
$14.00/25mL
15307-79-6
901 suppliers
$14.00/5g