Sodium Pyrithione synthesis
- Product Name:Sodium Pyrithione
- CAS Number:3811-73-2
- Molecular formula:C5H6NNaOS
- Molecular Weight:151.16
Sodium pyrithione (NPT) is the most effective water-soluble industrial anti-mildew preservative. It has the characteristics of high efficiency, broad spectrum, low toxicity and stability. It can be used in metal cutting fluid, anti-rust fluid, latex paint, adhesive, leather Products, textile products, coated paper and other fields. The generally synthesis route for making Sodium Pyrithione is by the mercaptization of a 2-halopyridine-N-oxide with an alkali metal sulfide or hydrosulfide and a base to make an alkali metal pyrithione and then converting this alkali metal salt to Sodium Pyrithione by reaction with a Sodium salt (e.g., NaClor NaSO4).
2402-95-1
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3811-73-2
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Yield:3811-73-2 1218 g
Reaction Conditions:
with sodium hydrogen sulfide;sodium hydroxide in water at 60 - 65; for 2.5 h;Large scale;
Steps:
2 Example 2
A pre-prepared sodium hydrosulfide solution (150 g 70% solids + 150 g deionized water) and 286.7 g of hydroxideSodium solution (24.88%) was added to the four-necked flask,After the temperature was raised to 60 ° C, 2-chloropyridine nitrogen oxide solution was added dropwise, and the reaction was carried out at 65 ° C after 1 h of dropping, and the reaction was completed after 1.5 h. After cooling to 45 ° C, 31% hydrochloric acid was added dropwise, the pH of the reaction solution was adjusted to about 6.1, and then 1.5 g of powdered activated carbon was added. The mixture was stirred for 1 h and then filtered to obtain a 2-mercaptopyridine oxide sodium salt solution at a mass of 1218 g,The content of mercapto-sodium was 20.12%, and the yield of the two-step reaction was 93.81%.
References:
Jiangsu Zhongbang Pharmaceutical Co., Ltd.;Xue, Yi;Ding, Yongshan;Zhan, Xinhua;Xu, Qiang;Li, Weisi;Zhao, Huayang CN106588762, 2017, A Location in patent:Paragraph 0043; 0045
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3811-73-2
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3811-73-2
428 suppliers
$18.00/25g