TAUROURSODEOXYCHOLIC ACID SODIUM SALT synthesis
- Product Name:TAUROURSODEOXYCHOLIC ACID SODIUM SALT
- CAS Number:35807-85-3
- Molecular formula:C26H46NNaO6S
- Molecular Weight:523.7
Yield:-
Reaction Conditions:
in water;acetone; for 0.5 h;
Steps:
1
Preparation of crude tauroursodeoxycholic acid (TUDCA); Approx. 30 minutes after the end of hydrolysis, 87 kg of concentrated (33% wt./wt.) hydrochloric acid solution are added. Stirring of the suspension is continued for 60 minutes. Precipitation of the sodium chloride and the taurine takes place. The suspension is centrifuged. Approx. 2300 litres of acetone are added to the filtered solution. After approx. 60 minutes, the crude TUDCA starts to precipitate out. Stirring is continued for 12 hours. The crude TUDCA is separated by centrifugation. Wet yield approx. 350 kg. Determination of the chromatographic quality of the crude TUDCA reveals the following results: impurities <0.3%; taurine <0.5%; ursodeoxycholic acid <0.5%.
References:
EP1985622,2008,A1 Location in patent:Page/Page column 4
107-35-7
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