Telatinib synthesis
- Product Name:Telatinib
- CAS Number:332012-40-5
- Molecular formula:C20H16ClN5O3
- Molecular Weight:409.83
332013-43-1
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![Furo[2,3-d]pyridazin-4-amine, 7-chloro-N-(4-chlorophenyl)-](/CAS/20180703/GIF/332013-40-8.gif)
332013-40-8
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332012-40-5
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Yield:332012-40-5 46%
Reaction Conditions:
with potassium hydroxide;18-crown-6 ether in toluene at 83 - 87;Product distribution / selectivity;
Steps:
14; 14A
To a mixture of the Intermediate from Example 9, step 5 (10.0 g, 35.7 mmol), Intermediate H (12.4 g, 74.6 mmol), and 18-crown-6 (0.42 g, 1.59 mmol) in toluene (100 mL) was added KOH powder(4.4 g, 85%, 66.7 mmol) in one portion at room temperature. The reaction mixture was then heated to 85 +/- 2°C under vigorous stirring. The reaction mixture was stirred vigorously at this temperature overnight. After it was cooled to room temperature, toluene solution was decanted off and water (100 mL) was added to the gummy residue. The resulting mixture was stirred vigorously until it became a free flowing suspension. The solids were collected by filtration, washed with water (2 x 10 mL), and dried under vacuum at 45°C for 16 hours. The yellow/brown solids were suspended in acetonitrile (70 mL) and the suspension was stirred at reflux for 2 hours. After it was
References:
BAYER HEALTHCARE AG WO2007/118602, 2007, A1 Location in patent:Page/Page column 68; 69; 75; 79
332013-40-8
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1182334-19-5
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332012-40-5
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332013-43-1
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![Furo[2,3-d]pyridazin-7-amine, 4-chloro-N-(4-chlorophenyl)-](/CAS/20180808/GIF/332013-41-9.gif)
332013-41-9
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332012-40-5
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$80.00/5mg
332013-42-0
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332012-40-5
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![Furo[2,3-d]pyridazine, 4,7-dichloro](/CAS/GIF/13177-70-3.gif)
13177-70-3
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332012-40-5
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$80.00/5mg