TERT-BUTYL PROPIOLATE synthesis
- Product Name:TERT-BUTYL PROPIOLATE
- CAS Number:13831-03-3
- Molecular formula:C7H10O2
- Molecular Weight:126.15
471-25-0
75-65-0
13831-03-3
General procedure for the synthesis of tert-butyl propargylate from propargyl acid and tert-butanol: About 60 g of propargyl acid, about 100 g of N,N'-dicyclohexylcarbodiimide, about 10 g of 4-(dimethylamino)pyridine, and about 20 g of tert-butanol were dissolved in tetrahydrofuran, and the reaction was stirred for about 24 hours. Upon completion of the reaction, extraction was carried out with dichloromethane and water. The extracted organic layer was dried with a chemical desiccant and subsequently purified by column chromatography to give about 80 g of tert-butyl propargylate.
471-25-0
238 suppliers
$10.00/1g
75-65-0
790 suppliers
$10.00/10ml
13831-03-3
175 suppliers
$26.00/1g
Yield:13831-03-3 80 g
Reaction Conditions:
with dmap;dicyclohexyl-carbodiimide in tetrahydrofuran for 24 h;
Steps:
7 Synthesis of Compound 18
Approximately 60g of compound 17 (propiolic acid), N of about 100 g, N'-dicyclohexylcarbodiimide (N, N'-dicyclohexylcarbodiimide), about 10g of 4- (dimethylamino) pyridine (4- (dimethylamino ) pyridine)), and about 20g of tert- butanol (tert-butanol), it was dissolved in tetrahydrofuran and stirred for about 24 hours.After extraction with dichloromethane and water, the extracted organic layer was chemically dried and purified by column chromatography to give compound 18 of about 80 g.
References:
LG Chem Limited;Min Hyung, Lee;Yong Ji, Son;Sung-Ho, Chun;Kyung Chang, Seo;Hyeong Bin, Jang;Ji Yong, Choe JP2016/533394, 2016, A Location in patent:Paragraph 0103
115-11-7
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471-25-0
238 suppliers
$10.00/1g
13831-03-3
175 suppliers
$26.00/1g
540-88-5
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471-25-0
238 suppliers
$10.00/1g
13831-03-3
175 suppliers
$26.00/1g